Journal of Heterocyclic Chemistry p. 1202 - 1209 (2014)
Update date:2022-07-30
Topics:
Soliman, Ahmed M.
Mohamed, Shaaban K.
El-Remaily, Mahmoud. Abd El Aleem. Ali. Ali.
Abdel-Ghany
The biologically active compounds of pyrimidine, dihydropyrimidinone, and dihydroimidazole have been synthesized in excellent yield under free solvent conditions. The antibacterial evaluation of the products showed a high inhibitory effect. Reaction of 2-guanidinobenzothiazole with several active methylene compounds has revealed formation of the corresponding pyrimidine, dihydropyrimidinone, and dihydroimidazole derivatives under free solvent conditions in very good yield. All compounds have been characterized on the basis of IR, 1H NMR, 13C NMR, mass spectrometry, and X-ray.
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