Trifluoromethyl ketones from carboxylic acids. Part II. A versatile access to trifluoromethylated heterocycles.

Article abstract of DOI:10.1016/0040-4020(95)00007-U

Various trifluoromethylated heterocycles can be prepared in good yield from carboxylic acid chlorides by reaction with pyridine and trifluoroacetic anhydride followed by capture of the intermediate trifluoroacyl ketene with suitable reagents.