Orally Active β-Lactam Inhibitors of Human Leukocyte Elastase. 3. Stereospecific Synthesis ans Structure-Activity Relationships for 3,3-Dialkylazetidin-2-ones

DOI: 10.1021/jm00013a021

Source and publish data:

Journal of Medicinal Chemistry p. 2449 - 2462 (1995)

Update date:2022-08-05

Topics:

Authors:

Finke, Paul E.

Shah, Shrenik K.

Fletcher, Daniel S.

Ashe, Bonnie M.

Brause, Karen A.

et al. et al.

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Article abstract of DOI:10.1021/jm00013a021

The stereospecific synthesis of several 4-<(4-carboxyphenyl)oxy>-3,3-dialkyl-1-<<(1-phenylalkyl)amino>carbonyl>azetidin-2-ones 3 is described in which the C-3 alkyl groups were varied from methyl to butyl as well as allyl, benzyl and methoxymethyl.The str

Full text of DOI:10.1021/jm00013a021

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