Journal of Medicinal Chemistry p. 1865 - 1871 (1995)
Update date:2022-08-03
Topics:
Nagasawa
Kawle
Elberling
DeMaster
Fukuto
The synthesis and the chemical/biological properties of N- hydroxysaccharin (1) (2-hydroxy-1,2-benzisothiazol-3(2H)-one 1,1-dioxide), a nitroxyl prodrug, are described. When treated with 0.1 M aqueous NaOH, 1 liberated nitroxyl (HN=O), a known inhibitor o
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