Prodrugs of nitroxyl as potential aldehyde dehydrogenase inhibitors vis- a-vis vascular smooth muscle relaxants

Article abstract of DOI:10.1021/jm00011a005

The synthesis and the chemical/biological properties of N- hydroxysaccharin (1) (2-hydroxy-1,2-benzisothiazol-3(2H)-one 1,1-dioxide), a nitroxyl prodrug, are described. When treated with 0.1 M aqueous NaOH, 1 liberated nitroxyl (HN=O), a known inhibitor o