Novel chiral tetramic acid-derived diols: Organocatalytic facile synthesis and unique structural properties

Article abstract of DOI:10.1039/c4ra05405a

Organocatalytic tandem reactions of l-phenylalanine-derived tetramic acid with aldehydes allow a one-pot and high-yielding access to a diverse range of novel chiral diols in enantiomerically pure forms. In addition, a new entry of the diols, featuring their unique structures associated with C_2- and pseudo C_2--symmetric chiral motifs, is reported.