Suppression of the Mattox Rearrangement of 16α-Cyanoprednisolones in Acid: Synthesis of Methyl 16α-Prednisolonecarboxylates

Article abstract of DOI:10.1016/0040-4039(95)00526-I

Prednisolone derivatives with a 16α-methyl carboxylate group were synthesized by a novel procedure of 1,3-dipole addition of fulminic acid to 21-acetyloxy-11β-hydroxy-3,20-dioxo-1,4,16-pregnatriene, followed by base-catalyzed ring opening of the resulting