The Discovery and Structure-Activity Relationships of 1,2,3,6-Tetrahydro-4-phenyl-1-pyridines. Dopamine Autoreceptor Agonists and Potential Antipsychotic Agents

DOI: 10.1021/jm00047a010

Source and publish data:

Journal of Medicinal Chemistry p. 3523 - 3533 (1994)

Update date:2022-07-30

Topics:

Authors:

Wright, Jon L.

Caprathe, Bradley W.

Downing, Dennis M.

Glase, Shelly A.

Heffner, Thomas G.

et al. et al.

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Article abstract of DOI:10.1021/jm00047a010

A novel dopamine (DA) autoreceptor agonist, 1,2,3,6-tetrahydro-4-phenyl-1-<(3-phenyl-3-cyclohexen-1-yl)methyl>pyridine (14), was identified.The structure-activity relationships surrounding this compound were studied by synthesis of analogues and evaluatio

Full text of DOI:10.1021/jm00047a010

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