Thieno[2,3-d]pyrimidine-3-acetic acids a new class of nonpeptide endothelin receptor antagonists

DOI: 10.1248/cpb.46.1724

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1724 - 1737 (1998)

Update date:2022-08-03

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Authors:

Cho, Nobuo

Nara, Yoshi

Harada, Mioko

Sugo, Tsukasa

Masuda, Yasushi

Abe, Akemi

Kusumoto, Keiji

Itoh, Yasuaki

Ohtaki, Tetsuya

Watanabe, Toshifumi

Furuya, Shuichi

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Article abstract of DOI:10.1248/cpb.46.1724

On the basis of structural information for the cyclic hexapeptide endothelin (ET) receptor antagonist, TAK-044, a series of thieno[2,3- d]pyrimidine-2,4-dione derivatives bearing a carboxyl group and aromatic rings that were important for receptor binding

Full text of DOI:10.1248/cpb.46.1724

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Product name:ethyl 6-(4-methoxyphenyl)-5-methyl-1-(2-methylaminobenzyl)-2,4-dioxo-1,2,3,4-tetrahydrothienol<2,3-d>pyrimidine-3-acetate

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