Synthesis of highly functionalized, enantiomerically and diastereomerically pure cyclohexane derivates via Michael addition of chiral 3-tosyl-2-(2-oxoalkyl)-1,3-oxazolidines and methyl vinyl ketone

Article abstract of DOI:10.1055/s-1994-25687

2-(2-Oxocycloalkyl)- or 2-phenylacyl-3-tosyl-1,3-oxazolidines 1, 2, 9, and 10 undergo with 3-buten-2-one highly diastereoselective Michael additions under the influence of cesium carbonate to yield 1,5-diketones 8 or 11, respectively. Intramolecular aldol