Conformationally Constrained Peptides. Chirospecific Synthesis of 4-Alkyl-Substituted γ-Lactam-Bridged Dipeptides from L-Aspartic Acid

DOI: 10.1021/jo00274a037

Source and publish data:

Journal of Organic Chemistry p. 3164 - 3173 (1989)

Update date:2022-08-04

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Authors:

Wolf, Jean-Pierre

Rapoport, Henry

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Article abstract of DOI:10.1021/jo00274a037

The synthesis of enantiomerically pure γ-lactam-bridged dipeptide analogues of Val-Ala, Ile-Ala, and β-MeLeu-Ala starting from L-aspartic acid is presented.N-(9-Phenylfluorenyl)-L-aspartic acid α-tert-butyl β-methyl diester and N-(9-Phenylfluorenyl)-L-asp

Full text of DOI:10.1021/jo00274a037

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