Preparation and Pharmacological Evaluation of Enantiomers of Certain Nonoxygenated Aporphines: (+)- and (-)-Aporphine and (+)- and (-)-10-Methylaporphine

Article abstract of DOI:10.1021/jm00062a002

The subject compounds were prepared as a part of a continuing structure-activity study of the contrasting actions (agonism-antagonism) of (+)- and (-)-11-hydroxy-10-methylaporphine at serotonin (5-HT_1A) receptors. None of the targeted nonoxygen