Chemistry of Insect Antifeedants from Azadirachta Indica (Part 19): A Potential Relay Route for the Synthesis of Azadirachtin.

Article abstract of DOI:10.1016/0040-4020(95)00297-L

A potential relay route for the synthesis of azadirachtin (1) has been established.An advanced intermediate 4 has been prepared and methods to convert this back to the natural product has been developed, in particular, the reintroduction of the enol double bond using an acetal exchange process.