Novel benzo[b]quinolizinium cations as uncompetitive N-methyl-D-aspartic acid (NMDA) antagonists: The relationship between log D and agonist independent (closed) NMDA channel block

DOI: 10.1021/jm00018a018

Source and publish data:

Journal of Medicinal Chemistry p. 3586 - 3592 (1995)

Update date:2022-08-02

Topics:

Authors:

Earley Earley

Kumar Kumar

Mallamo Mallamo

Subramanyam

Dority Jr.

Miller Miller

DeHaven-Hudkins

Aimone Aimone

Kelly Kelly

Ault Ault

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00018a018

A series of permanently charged benzo[b]quinolizinium cations having lower lipophilicity than MK-801 or phencyclidine (PCP) were synthesized. Data relating agonist independent block of N-methyl-D-aspartic acid (NMDA) ion channels to log D are described. C

Full text of DOI:10.1021/jm00018a018

Products guided by the article

Product name:2-Pyridinemethanol, a-[2,6-bis[[(tetrahydro-2H-pyran-2-yl)oxy]methyl]phenyl]-

Cas No:167166-38-3

R&D Labs maybe for 167166-38-3

Fujian Huitian Biological Pharmacy Co., Ltd.

Contact:0086-598-8300831; 8339920

Address:No.46,Taijiang Road,Sanming City,Fujian,China
Shuanghe Bio-Technology Limited(expird)

Contact:+86-571-61710758,18968016640

Address:Jinqiao north road 916# Fuyang
Xi'an Herbland Tech Inc.

Contact:+86-29-88710656

Address:South Tai bai Road, High Tech Development Zone, Xi'an China
Lonwin Chemical Group Limited

website:http://www.lonwinchem.com

Contact:Tel: 86-21-59858395

Address:No#966,Huaxu Road,Shanghai 201702,P.R.China
Taixing Shenfeng Chemical Co., Ltd.

Contact:+86-523-87117033, 87117666

Address:4# Yinsanlu, Huangqiao town, Taixing, Jiangsu, China.

Relevant to this article

Doi:10.1021/jm00255a026
(1974)
The synthesis and reactivity of new 2-(N,N-diisopropylamino)-3-methylsulfonyl-1,3,2-benzoxazaphospholes. The utility of the 5-chloro analogue in the one-pot synthesis of oligothiophosphates: [Ap_SppA, Ap_SpppA, ppp5′A2′p_S5′A, m⁷Gp_SppA, Ap_Spppp, Ap_sPP]

Doi:10.1016/0040-4020(95)00031-3
(1995)
Studies on the Stereochemistry of Aplyronine A: Determination of the Stereochemistry of the C21-C34 Fragment

Doi:10.1016/S0040-4039(00)61370-9
(1993)
Pyrrolylquinoxalinediones: A new class of AMPA receptor antagonists

Doi:10.1016/S0960-894X(96)00534-3
(1996)
Synthesis and cytotoxicity of novel γ-piperidone-containing dibenzo-1,7-diaza-14-crown-4 ethers

Doi:10.1016/j.mencom.2019.07.004
(2019)
Studies related to the carbohydrate sectors of esperamicin and calicheamicin: Definition of the stability limits of the esperamicin domain and fashioning of a glycosyl donor from the calicheamicin domain

Doi:10.1021/ja00126a013
(1995)

Article Doi