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Novel benzo[b]quinolizinium cations as uncompetitive N-methyl-D-aspartic acid (NMDA) antagonists: The relationship between log D and agonist independent (closed) NMDA channel block

DOI: 10.1021/jm00018a018

Source and publish data:

Journal of Medicinal Chemistry p. 3586 - 3592 (1995)

Update date:2022-08-02

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Authors:

EarleyEarley

KumarKumar

MallamoMallamo

SubramanyamSubramanyam

Dority Jr.Dority Jr.

MillerMiller

DeHaven-HudkinsDeHaven-Hudkins

AimoneAimone

KellyKelly

AultAult

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Article abstract of DOI:10.1021/jm00018a018

A series of permanently charged benzo[b]quinolizinium cations having lower lipophilicity than MK-801 or phencyclidine (PCP) were synthesized. Data relating agonist independent block of N-methyl-D-aspartic acid (NMDA) ion channels to log D are described. C

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Full text of DOI:10.1021/jm00018a018

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Cas No:167166-38-3

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