Bioorganic and Medicinal Chemistry Letters p. 2887 - 2892 (1996)
Update date:2022-08-02
Topics:
Lubisch
Behl
Hofmann
Pyrrolylquinoxalinediones were synthesized and their affinities for the AMPA receptor were determined. Most compounds showed moderate to good affinities. The acetic acid derivative 8b exhibited a K(i) value of 70 nM and was equipotent to NBQX 1. Structure activity relationships are discussed. Selected compounds were tested for their potency to inhibit AMPA induced lethal convulsions in mice. In this in vivo model the compounds showed improved potency compared with NBQX.
View MoreShandong Wanda Organosilicon New Material Co., Ltd
Contact:+86-21-54177116;54302881
Address:R1318 Greenland No. 3 Lane 58 Xinjian East Rd., Minhang
Luojiang Chenming Biological Products Co
Contact:+86 15000297032
Address:GROUP NO.4, HE SHENG VILLAGE, PANLONG TOWN,
Contact:18698110882
Address:1303 No2 building,LuoMa Garden,YongAn Road,Hexi District,Tianjin city
Suzhou Lixin Pharmaceutical Co., Ltd.
Contact:86-512-88169812
Address:21 Tangxi Road, Suzhou New District, Suzhou 215151
Contact:+86-518-81061113
Address:No. 8 Lingzhou Road, Lianyungang, Jiangsu, China
Doi:10.1021/jm00017a003
(1995)Doi:10.1021/j100210a015
(1982)Doi:10.1016/0031-9422(95)00213-Q
(1995)Doi:10.1016/0022-328X(94)05067-L
(1995)Doi:10.1039/c39950001317
(1995)Doi:10.1021/jo00129a040
(1995)
