A short, convergent synthesis of two chiral antiviral agents, (+) carbocyclic 2′-deoxy-5-[(E)-2-bromovinyl] uridine and (+) carbocyclic 2′-deoxyguanosine

DOI: 10.1016/00404-0399(50)1372O-

Source and publish data:

Tetrahedron Letters p. 6929 - 6932 (1995)

Update date:2022-08-03

Topics:

Authors:

Borthwick, Alan D.

Crame, Andrew J.

Exall, Anne M.

Weingarten, Gordon G.

Mahmoudian, Mahmuod

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Article abstract of DOI:10.1016/00404-0399(50)1372O-

Stereo selective microbial reduction of ketone 2 gave the alcohol 5 which was coupled under Mitsunobu conditions with the protected pyrimidine 7 and purine 10 to give on deprotection the chiral antiviral nucleosides (+) carbocyclic 2′-deoxy-5-[(E)-2bromov

Full text of DOI:10.1016/00404-0399(50)1372O-

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