Probing the Hydrophobic Pocket of the Active Site of Aromatase with 4-Phenoxy-7α-(phenylthio)-4-androstene-3,17-dione

Article abstract of DOI:10.1021/jm00020a031

In order to examine the nature of the hydrophobic pocket at the active site of aromatase, we carried out the synthesis, biochemical evaluation, and molecular modeling studies on 4-phenoxy-7α-(phenylthio)-4-androstenedione 2.Aromatase inhibitory activity o