Probing the Hydrophobic Pocket of the Active Site of Aromatase with 4-Phenoxy-7α-(phenylthio)-4-androstene-3,17-dione

DOI: 10.1021/jm00020a031

Source and publish data:

Journal of Medicinal Chemistry p. 4135 - 4138 (1995)

Update date:2022-08-05

Topics:

Authors:

Liu, Xing-Ping

Lambert, Didier M.

Abul-Hajj, Yusuf J.

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Article abstract of DOI:10.1021/jm00020a031

In order to examine the nature of the hydrophobic pocket at the active site of aromatase, we carried out the synthesis, biochemical evaluation, and molecular modeling studies on 4-phenoxy-7α-(phenylthio)-4-androstenedione 2.Aromatase inhibitory activity o

Full text of DOI:10.1021/jm00020a031

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