Manipulation of the aldol adducts from lactate-derived ketones. A versatile chiral auxiliary for the asymmetric synthesis of β-hydroxy carbonyl compounds

Article abstract of DOI:10.1016/0040-4039(94)88435-8

The ketones 1 and 2 can be transformed into a wide range of enantiomerically-pure anti and syn α-methyl-β-hydroxy ketones and aldehydes. The α'-methyl group in 5 and 11 may be retained, demonstrating the use of the lactate-derived group as an optional chi