Bioorganic and Medicinal Chemistry Letters p. 865 - 870 (1997)
Update date:2022-08-05
Topics:
Prugh, John D.
Gould, Robert J.
Lynch, Robert J.
Zhang, Guixiang
Cook, Jacquelynn J.
Holahan, Marie A.
Stranieri, Maria T.
Sitko, Gary R.
Gaul, S. Lee
Bednar, Rodney A.
Bednar, Bohumil
Hartman, George D.
Centrally constrained thieno[2,3-b]thiophene sulfonamides have provided a potent, selective, orally active series of platelet aggregation inhibitors. Compound 21 showed excellent activity in the dog after a single oral dose of 200 μg/kg.
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