Nonpeptide GPIIb/IIIa inhibitors. 16. Thieno[2,3-b]thiophene α-sulfonamides are potent inhibitors of platelet aggregation

DOI: 10.1016/S0960-894X(97)00120-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 865 - 870 (1997)

Update date:2022-08-05

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Authors:

Prugh, John D.

Gould, Robert J.

Lynch, Robert J.

Zhang, Guixiang

Cook, Jacquelynn J.

Holahan, Marie A.

Stranieri, Maria T.

Sitko, Gary R.

Gaul, S. Lee

Bednar, Rodney A.

Bednar, Bohumil

Hartman, George D.

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Article abstract of DOI:10.1016/S0960-894X(97)00120-0

Centrally constrained thieno[2,3-b]thiophene sulfonamides have provided a potent, selective, orally active series of platelet aggregation inhibitors. Compound 21 showed excellent activity in the dog after a single oral dose of 200 μg/kg.

Full text of DOI:10.1016/S0960-894X(97)00120-0

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