Journal of Medicinal Chemistry p. 3608 - 3616 (1995)
Update date:2022-08-05
Topics:
Chan
Hong
Kuyper
Baccanari
Joyner
Tansik
Boytos
Rudolph
The recent increase in fungal infections, especially among AIDS patients, has resulted in the need for more effective antifungal agents. In our search for such agents, we focused on developing compounds which inhibit fungal dihydrofolate reductase (DHFR).
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