(Aryloxy)methylsilane Derivatives as New Cholesterol Biosynthesis Inhibitors: Synthesis and Hypocholesterolemic Activity of a New Class of Squalene Epoxidase Inhibitors

DOI: 10.1021/jm00017a004

Source and publish data:

Journal of Medicinal Chemistry p. 3207 - 3216 (1995)

Update date:2022-08-05

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Authors:

Gotteland, Jean-Pierre

Brunel Isabelle

Gendre, Fabrice

Desire, Jerome

Delhon, Andre

at al. at al.

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Article abstract of DOI:10.1021/jm00017a004

A series of 3-substituted (aryloxy)silane derivatives of benzylamine (4' 4', or 4") was synthesized and evaluated for hypocholesterolemic activity.Most of the new silane derivatives were identified as potent inhibitors of pig liver squalene epoxidase with

Full text of DOI:10.1021/jm00017a004

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