A new route of 5,6-diarylpyridazin-3-ones by metalation and cross-coupling of pyridazines

DOI: 10.1002/jhet.5570320364

Source and publish data:

Journal of Heterocyclic Chemistry p. 1057 - 1062 (1995)

Update date:2022-08-02

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Authors:

Trecourt

Turck Turck

Ple Ple

Paris Paris

Queguiner

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Article abstract of DOI:10.1002/jhet.5570320364

Starting from 3,6-dichloropyridazine, a new route is described to antihypertensive 5,6-diarylpyridazin-3-ones. This pathway comprises the regioselective metalation followed by a substitution of the trimethylsilyl moiety. The introduction of iodine by anot

Full text of DOI:10.1002/jhet.5570320364

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