Synthesis of protected 3',5'-di-2'-deoxythymidine-(α-hydroxy-2- nitrobenzyl)-phosphonate diesters as dimer building blocks for oligonucleotides

Article abstract of DOI:10.1080/15257779508012475

The synthesis of 3'-succinyl-CPG bound 3',5'-di-2'-deoxythymidyl-(α- hydroxy-2-nitrobenzyl)-phosphonate diester 1 and the 3'-phosphoamidite derivative 2 is described. The hydroxyl-groups of the backbone modification were protected with trialkylsilyl group

Full text of DOI:10.1080/15257779508012475

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Synthesis of Protected 3′,5′-Di-2′-
Deoxythymidine-(α-hydroxy-2-
nitrobenzyl)-phosphonate Diesters
as Dimer Building Blocks for
Oligonucleotides
Chris Meier a & Ralf Mauritz a
a Institute of Organic Chemistry, University of Frankfurt , Marie-
Curie-Str. 11, D-60439, Frankfurt/Main, Germany
Published online: 16 Feb 2007.
To cite this article: Chris Meier & Ralf Mauritz (1995) Synthesis of Protected 3′,5′-Di-2′-
Deoxythymidine-(α-hydroxy-2-nitrobenzyl)-phosphonate Diesters as Dimer Building Blocks for
Oligonucleotides, Nucleosides and Nucleotides, 14:3-5, 803-804
To link to this article: http://dx.doi.org/10.1080/15257779508012475
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