Simple total syntheses of N-substituted polyamine derivatives using N-tritylamino acids

Article abstract of DOI:10.1016/0040-4039(95)01010-F

A general methodology for the total synthesis of N-alkyl- and acylpolyamine derivatives is described which is based on the coupling of suitable N-tritylamino acids with amines followed by lithium aluminium hydride reduction of the thus obtained amides.