The stereospecific synthesis of (2S,3R) 3-carboxyproline and (2S,3R) 3-aminoproline

Article abstract of DOI:10.1016/0040-4020(95)98712-Q

Stereospecific syntheses of (2S,3R) 3-carboxyproline and (2S,3R) 3-aminoproline are reported which make use of the stereospecific alkylation of (4S)-N-(t-butyldimethylsilyl)azetidin-2-one 4-carboxylic acid with the cyclic sulfate derived from ethylene glycol.