Synthesis of 1,3,4,5-Tetrahydropyrrolo-quinolines via the Vicarious Nucleophilic Substitution of Hydrogen

Article abstract of DOI:10.1016/0040-4020(95)00350-H

The VNS reaction was used as key steps in synthesis of O-methylnordehydrobufotenine and its 8-methoxy isomer starting from simple benzene derivatives.Attempts to use nitrobenzoxazole derivatives as a starting material were made.Several approaches were developed but all of them failed to produce the desired ring system on various stages of synthesis.