Synthesis, conformational analysis, and biological activity of a rigid carbocyclic analogue of 2'-deoxy aristeromycin built on a bicyclo[3.1.0]hexane template

Article abstract of DOI:10.1080/07328319608002382

A new chiral synthesis of the pseudosugar synthon (1R,2S,4R,5S)-1-[(benzyloxy)methyl]-2-tert-butyloxy-4-hydroxybicyclo[3 .1.0]hexane (12) is reported. This compound was used as a template for the construction of carbocyclic nucleoside 4, a conformationall

Full text of DOI:10.1080/07328319608002382

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Synthesis, Conformational Analysis,
and Biological Activity of a Rigid
Carbocyclic Analogue of 2′-
Deoxy Aristeromycin Built on a
Bicyclo[3.1.0]hexane Template
Maqbool A. Siddiqui a , Harry Ford Jr. a , Clifford George b
Victor E. Marquez a
&
a Laboratory of Medicinal Chemistry, Developmental
Therapeutics Program, Division of Cancer Treatment , National
Cancer Institute, National Institutes of Health , Bethesda, MD,
20892
b Laboratory for the Structure of Matter, Naval Research
Laboratory , Washington, DC, 20375
Published online: 21 Aug 2006.
To cite this article: Maqbool A. Siddiqui , Harry Ford Jr. , Clifford George & Victor E. Marquez
(1996) Synthesis, Conformational Analysis, and Biological Activity of a Rigid Carbocyclic
Analogue of 2′-Deoxy Aristeromycin Built on a Bicyclo[3.1.0]hexane Template , Nucleosides and
Nucleotides, 15:1-3, 235-250
To link to this article: http://dx.doi.org/10.1080/07328319608002382
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