Dicationic 2-fluorenonylcarbapenems: Potent anti-MRS agents with improved solubility and pharmacokinetic properties

DOI: 10.1016/S0960-894X(99)00567-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3225 - 3230 (1999)

Update date:2022-08-02

Topics:

Authors:

Greenlee, Mark L.

Laub, Joanne B.

Rouen, Gregory P.

DiNinno, Frank

Hammond, Milton L.

Huber, Joann L.

Sundelof, Jon G.

Hammond, Gail G.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00567-3

The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl substituent was found to improve pharmacokinetics.

Full text of DOI:10.1016/S0960-894X(99)00567-3

Products guided by the article

Product name:(4S,5R,6S)-3-(7-Iodomethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Cas No:169957-60-2

R&D Labs maybe for 169957-60-2

Jinan Jianfeng Chemical Co., Ltd

Contact:0086-531-88110457

Address:sales01(-a-t-)pharmachemm{dot}c+o+m
JIANGXI AIFEIMU TECHNOLOGY CO.，LTD

Contact:+86-570-6040289

Address:FINECHEMICAL PARK,ZIBU TOWN,WANNIAN COUNTY,JIANGXI PROV.,CHINA,ZIP
Changsha Yonta Industry Co., Ltd.

Contact:+ 86-731-8535 2228

Address:Rm.1717, North Bldg., No.368, East 2nd Ring Road(2nd Section)
Fusilin chemical science & technology co., ltd.

Contact:532-80698166/86057573, +86-400-669-7885

Address:School of Material Science & Engineering, Shandong Uinversity of Science & Technology, Huangdao Zone, Qindao, Shandong
Guangzhou Congen Pharmatec Co.,Ltd.

website:https://www.congenpharma.com

Contact:86-020-82350801

Address:Room 501, Building G11, South China Advanced Materials Innovation Park, 31 Kefeng Road, Science City, Guangzhou, China 510663

Relevant to this article

Synthesis and Cyclization of 2-Amino- and 2-Methyl-Substituted 1,3-Diaminobenzimidazolium Salts

Doi:10.1007/s10593-014-1627-8
(2015)
Preparation of olefins and acetylenes via reductive elimination with Sml₂-HMPA

Doi:10.1016/0040-4020(95)00565-P
(1995)
SYNTHESES BASED ON &β-PHENYLETHYLAMINES V. SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL SCREENING OF SOME PHENYLALKYLAMINES AND N-BENZYLTETRAHYDROISOQUINOLINES

Doi:10.1007/BF00630218
(1993)
Chiral recognition of amino-acid esters by a glucose-derived macrocyclic receptor

Doi:10.1039/d1cc00878a
(2021)
Preparation of some cyclopentadienyl titanium complexes and crystal structure of (η5-pentamethylcyclopentadienyl) {(1R,2S,3R)-exo-3[(R)-2-phenyl-2-olato-ethyl] sulphenyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-olato} chlorotitanium(IV): [Cp*Ti(OC18H24SO)Cl]

Doi:10.1016/0277-5387(95)00113-7
(1995)
N-O diheterocyclic nucleosides: Synthesis of 2'-N-methyl-3'-hydroxymethyl-1',2'-isoxazolidinylthymidine

Doi:10.1016/0040-4039(95)01499-8
(1995)

Article Doi