Dicationic 2-fluorenonylcarbapenems: Potent anti-MRS agents with improved solubility and pharmacokinetic properties

DOI: 10.1016/S0960-894X(99)00567-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3225 - 3230 (1999)

Update date:2022-08-02

Topics:

Authors:

Greenlee, Mark L.

Laub, Joanne B.

Rouen, Gregory P.

DiNinno, Frank

Hammond, Milton L.

Huber, Joann L.

Sundelof, Jon G.

Hammond, Gail G.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00567-3

The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl substituent was found to improve pharmacokinetics.

Full text of DOI:10.1016/S0960-894X(99)00567-3

Products guided by the article

Product name:(4S,5R,6S)-3-(7-Iodomethyl-9-oxo-9H-fluoren-3-yl)-4-methyl-7-oxo-6-((R)-1-triethylsilanyloxy-ethyl)-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Cas No:169957-60-2

R&D Labs maybe for 169957-60-2

Chemieliva Pharmaceutical Co., Ltd.

website:http://www.chemieliva.com

Contact:+86-23-67770219

Address:99 Longhua Road, Yubei District, 401147, Chongqing, China Email: sales@chemieliva.com Tel:0086-23-67770219 Fax: 0086-23-67770220 Attn: Andy Huang
Hebei Fulong Import & Export Co., Ltd.

Contact:86-311-87795661

Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China
NINGBO YINLIANG FOREIGN TRADE CO., LTD.

Contact:+86-574-87834016 / 87898057

Address:23F NO.666JINYU ROAD,YINGZHOU DISTRICT,NINGBO.CHINA
Shenzhen Hongyuan Import & Export Co., Ltd.

Contact:0755-26407171

Address:Shenzhen Hongyuan Chemical New Materials Technology Co., Ltd.
Beijing Cooperate Pharmaceutical Co.,Ltd

website:http://www.cooperate-pharm.com/

Contact:86-01060279497

Address:No.507,Building 4,Tianhua Street, Biomedicine industrial Base

Relevant to this article

Synthesis and Cyclization of 2-Amino- and 2-Methyl-Substituted 1,3-Diaminobenzimidazolium Salts

Doi:10.1007/s10593-014-1627-8
(2015)
Preparation of olefins and acetylenes via reductive elimination with Sml₂-HMPA

Doi:10.1016/0040-4020(95)00565-P
(1995)
SYNTHESES BASED ON &β-PHENYLETHYLAMINES V. SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL SCREENING OF SOME PHENYLALKYLAMINES AND N-BENZYLTETRAHYDROISOQUINOLINES

Doi:10.1007/BF00630218
(1993)
Chiral recognition of amino-acid esters by a glucose-derived macrocyclic receptor

Doi:10.1039/d1cc00878a
(2021)
Preparation of some cyclopentadienyl titanium complexes and crystal structure of (η5-pentamethylcyclopentadienyl) {(1R,2S,3R)-exo-3[(R)-2-phenyl-2-olato-ethyl] sulphenyl-1,7,7-trimethylbicyclo[2.2.1]heptan-2-olato} chlorotitanium(IV): [Cp*Ti(OC18H24SO)Cl]

Doi:10.1016/0277-5387(95)00113-7
(1995)
N-O diheterocyclic nucleosides: Synthesis of 2'-N-methyl-3'-hydroxymethyl-1',2'-isoxazolidinylthymidine

Doi:10.1016/0040-4039(95)01499-8
(1995)

Article Doi