Bioorganic and Medicinal Chemistry Letters p. 3225 - 3230 (1999)
Update date:2022-08-02
Topics:
Greenlee, Mark L.
Laub, Joanne B.
Rouen, Gregory P.
DiNinno, Frank
Hammond, Milton L.
Huber, Joann L.
Sundelof, Jon G.
Hammond, Gail G.
The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl substituent was found to improve pharmacokinetics.
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