Dicationic 2-fluorenonylcarbapenems: Potent anti-MRS agents with improved solubility and pharmacokinetic properties

DOI: 10.1016/S0960-894X(99)00567-3

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 3225 - 3230 (1999)

Update date:2022-08-02

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Authors:

Greenlee, Mark L.

Laub, Joanne B.

Rouen, Gregory P.

DiNinno, Frank

Hammond, Milton L.

Huber, Joann L.

Sundelof, Jon G.

Hammond, Gail G.

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Article abstract of DOI:10.1016/S0960-894X(99)00567-3

The synthesis and biological evaluation of a series of dicationic-substituted 2-fluorenonylcarbapenems is described. This class of compounds showed enhanced water solubility while maintaining potent activity against MRS. Introduction of a 1-β-methyl substituent was found to improve pharmacokinetics.

Full text of DOI:10.1016/S0960-894X(99)00567-3

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