A Novel Pyrrolidine Analog of Histamine as a Potent, Highly Selective Histamine H3 Receptor Agonist

DOI: 10.1021/jm00010a003

Source and publish data:

Journal of Medicinal Chemistry p. 1593 - 1599 (1995)

Update date:2022-08-04

Topics:

Authors:

Shih, Neng-Yang

Lupo, Andrew T.

Aslanian, Robert

Orlando, Steven

Piwinski, John J.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00010a003

Employing classical conformational analysis on a known H₃ agonist, (R)-α-methylhistamine (1), a series of conformationally constrained H₃ agonists were proposed and synthesized.Pyrrolidine (+/-)-4a, a compound proposed to mimic the a

Full text of DOI:10.1021/jm00010a003

Products guided by the article

Product name:1-methyl-2-(1-(triphenylmethyl)-1H-imidazole-4-yl)nitroethene

Cas No:169566-13-6

R&D Labs maybe for 169566-13-6

Nanjing Spring & Autumn Biological Engineering Co., Ltd.

Contact:86-180510-83338

Address:Suite# 210, No. 1 BuildingNanjing Agricultural Biotechnology High-tech Entrepreneurship Center, No. 4 Tongwei Road, Xuanwu District, Nanjing,China
Ningbo Tide Imp. & Exp. Co., Ltd.

Contact:+86-571-8993 7933; +86-571-8993 6453

Address:7/F Anno Domini Building, Tower South, 8 Qiu Shi Road,Hangzhou,China.
Changzhou Kingyo Chemical Corporation Ltd.

website:http://www.kingyochem.com

Contact:+86-519-85105717

Address:19# Wuqing North Road, Changzhou , Jiangsu, China
Longhui qunfeng Chemical Co., Ltd

Contact:86-731-82173407

Address:South-east Industrial Park, Longhui County, Hunan Province, China
Fusilin chemical science & technology co., ltd.

Contact:532-80698166/86057573, +86-400-669-7885

Address:School of Material Science & Engineering, Shandong Uinversity of Science & Technology, Huangdao Zone, Qindao, Shandong

Relevant to this article

Studies on reactions of nucleoside H-phosphonates with bifunctional reagents. Part 3. Further studies on transesterification of nucleoside H- phosphonate diesters with amino alcohols

Doi:10.1080/15257779508012484
(1995)
Bridgehead-Substituted Bicyclo<3.3.1>nonenes and Their Benzo and Dibenzo Derivatives

Doi:10.1021/jo00122a070
(1995)
Design, synthesis and evaluation of the antibacterial activity of new Linezolid dipeptide-type analogues

Doi:10.1016/j.bioorg.2019.103483
(2020)
Beta 3 agonists. Part 1: Evolution from inception to BMS-194449

Doi:10.1016/S0960-894X(01)00628-X
(2001)
Doi:10.1016/S0020-1693(00)80616-7
(1988)
Synthetic utilization of polynitroaromatic compounds. 2. Synthesis of 4,6-dinitro-1,2-benzisothiazol-3-ones and 4,6-dinitro-1,2-benzisothiazoles from 2-benzylthio-4,6-dinitrobenzamides

Doi:10.1021/jo000480c
(2000)

Article Doi