A Novel Pyrrolidine Analog of Histamine as a Potent, Highly Selective Histamine H3 Receptor Agonist

DOI: 10.1021/jm00010a003

Source and publish data:

Journal of Medicinal Chemistry p. 1593 - 1599 (1995)

Update date:2022-08-04

Topics:

Authors:

Shih, Neng-Yang

Lupo, Andrew T.

Aslanian, Robert

Orlando, Steven

Piwinski, John J.

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00010a003

Employing classical conformational analysis on a known H₃ agonist, (R)-α-methylhistamine (1), a series of conformationally constrained H₃ agonists were proposed and synthesized.Pyrrolidine (+/-)-4a, a compound proposed to mimic the a

Full text of DOI:10.1021/jm00010a003

Products guided by the article

Product name:1-methyl-2-(1-(triphenylmethyl)-1H-imidazole-4-yl)nitroethene

Cas No:169566-13-6

R&D Labs maybe for 169566-13-6

Changzhou Sunsheng Chem Co., Ltd

Contact:+1-(989)-854-0648

Address:No. 28 Yinshan Rd., Xixiashu Industrial Park
Shandong Bolode Bio-Technology Co., LTD

Contact:+86-0531-58966870

Address:136 Jingyi Road,Huaiyin District,Jinan,Shandong,China
Shandong LuZhou Amino Acid Co., Ltd

Contact:86-539-2218025

Address:yishui economic and technical development zone zhenxing south road
Wuhan Konberd Biotech Co., Ltd.

Contact:+86-27-87205925

Address:NO.666, Gaoxin Road, Eastlake High-tech zone
Chengdu Pukang Biotechnology Co., Ltd

website:http://www.pu-kang.com

Contact:86-028-63976226

Address:No. 868 Xiwang Road,Xinjin county,Chengdu city, China

Relevant to this article

Studies on reactions of nucleoside H-phosphonates with bifunctional reagents. Part 3. Further studies on transesterification of nucleoside H- phosphonate diesters with amino alcohols

Doi:10.1080/15257779508012484
(1995)
Bridgehead-Substituted Bicyclo<3.3.1>nonenes and Their Benzo and Dibenzo Derivatives

Doi:10.1021/jo00122a070
(1995)
Design, synthesis and evaluation of the antibacterial activity of new Linezolid dipeptide-type analogues

Doi:10.1016/j.bioorg.2019.103483
(2020)
Beta 3 agonists. Part 1: Evolution from inception to BMS-194449

Doi:10.1016/S0960-894X(01)00628-X
(2001)
Doi:10.1016/S0020-1693(00)80616-7
(1988)
Synthetic utilization of polynitroaromatic compounds. 2. Synthesis of 4,6-dinitro-1,2-benzisothiazol-3-ones and 4,6-dinitro-1,2-benzisothiazoles from 2-benzylthio-4,6-dinitrobenzamides

Doi:10.1021/jo000480c
(2000)

Article Doi