A Novel Pyrrolidine Analog of Histamine as a Potent, Highly Selective Histamine H3 Receptor Agonist

DOI: 10.1021/jm00010a003

Source and publish data:

Journal of Medicinal Chemistry p. 1593 - 1599 (1995)

Update date:2022-08-04

Topics:

Authors:

Shih, Neng-Yang

Lupo, Andrew T.

Aslanian, Robert

Orlando, Steven

Piwinski, John J.

et al. et al.

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Article abstract of DOI:10.1021/jm00010a003

Employing classical conformational analysis on a known H₃ agonist, (R)-α-methylhistamine (1), a series of conformationally constrained H₃ agonists were proposed and synthesized.Pyrrolidine (+/-)-4a, a compound proposed to mimic the a

Full text of DOI:10.1021/jm00010a003

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