Studies on reactions of nucleoside H-phosphonates with bifunctional reagents. Part 3. Further studies on transesterification of nucleoside H- phosphonate diesters with amino alcohols

Article abstract of DOI:10.1080/15257779508012484

Reactions of 5'-O-(4,4'-dimethoxytrityl)thymidin-3'-yl 2-cyanoethyl phosphonate with alcohols, amines and amino alcohols in pyridine are described. Transesterification was found to be faster than β-elimination of 2-cyanoethyl group.

Full text of DOI:10.1080/15257779508012484

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Nucleosides and Nucleotides
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Studies on Reactions of Nucleoside
H-Phosphonates with Bifunctional
Reagents. Part III. Further Studies
on Transesterification of Nucleoside
H-Phosphonate Diesters with Amino
Alcohols
Michal Sobkowski a , Jacek Stawińki b , Anna Sobkowska a & Adam
Kraszewski a
a Institute of Bioorganic Chemistry, Polish Academy of Sciences ,
Noskowskiego, 12/14, 61-704, Pozné, Poland
b Department of Organic Chemistry, Arrhenius Laboratory ,
Stockholm University , S-10691, Stockholm, Sweden
Published online: 16 Feb 2007.
To cite this article: Michal Sobkowski , Jacek Stawińki , Anna Sobkowska & Adam Kraszewski (1995)
Studies on Reactions of Nucleoside H-Phosphonates with Bifunctional Reagents. Part III. Further
Studies on Transesterification of Nucleoside H-Phosphonate Diesters with Amino Alcohols, Nucleosides
and Nucleotides, 14:3-5, 839-842
To link to this article: http://dx.doi.org/10.1080/15257779508012484
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