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Oligonucleotides bearing cationic groups: N2-(3-aminopropyl)deoxyguanosine. Synthesis, enhanced binding properties and conjugation chemistry

DOI: 10.1016/0040-4039(96)01755-8

Source and publish data:

Tetrahedron Letters p. 7675 - 7678 (1996)

Update date:2022-07-30

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Authors:

Manoharan, MuthiahManoharan, Muthiah

Ramasamy, Kanda S.Ramasamy, Kanda S.

Mohan, VenkatramanMohan, Venkatraman

Cook, P. DanCook, P. Dan

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Article abstract of DOI:10.1016/0040-4039(96)01755-8

A phosphoramidite with an aminopropyl group placed at the N2-position of 2'-deoxyguanosine has been synthesized and incorporated into oligonucleotides. This modification shows enhanced binding properties against both DNA and RNA targets and is useful for conjugating other functionalities.

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Full text of DOI:10.1016/0040-4039(96)01755-8

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