Synthesis and anti-HIV activity of dibenzylbutyrolactone lignans

DOI: 10.1016/0960-894X(96)00158-8

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 941 - 944 (1996)

Update date:2022-07-30

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Authors:

Yang, Li-Ming

Lin, Shwu-Jiuan

Yang, Tsang-Hsiung

Lee, Kuo-Hsiung

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Article abstract of DOI:10.1016/0960-894X(96)00158-8

Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC₅₀ values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.

Full text of DOI:10.1016/0960-894X(96)00158-8

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