Bioorganic and Medicinal Chemistry Letters p. 941 - 944 (1996)
Update date:2022-07-30
Topics:
Yang, Li-Ming
Lin, Shwu-Jiuan
Yang, Tsang-Hsiung
Lee, Kuo-Hsiung
Five optically active dibenzylbutyrolactone lignans were synthesized through a lipase-catalyzed transesterification route and evaluated for their inhibitory activity against HIV-1 replication in acutely infected H9 cells. Compounds 1 and 2 demonstrated anti-HIV replication activity with an EC50 values of 2.2 and 0.16 μg/ml and a therapeutic index values of 9.1 and 5, respectively. Structure-antiviral activity relationships are discussed.
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Doi:10.1002/anie.199610021
(1996)Doi:10.1039/b002903n
(2000)Doi:10.1016/0040-4039(96)00557-6
(1996)Doi:10.1248/cpb.44.1026
(1996)Doi:10.1016/j.bmcl.2005.05.134
(2005)Doi:10.1016/S0040-4039(00)73014-0
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