Tetrahedron p. 5233 - 5254 (1997)
Update date:2022-08-03
Topics:
Baldwin, Jack E.
Bamford, Samantha J.
Fryer, Andrew M.
Rudolph, Martin P. W.
Wood, Mark E.
The first stages in the synthesis of acromelic acid analogues from trans-4-hydroxy-L-proline are described. An enamine alkylation was used to stereospecifically introduce the C-3 substituent, Grignard addition to a ketone or Pd(0) catalysed cross-coupling procedures adding C-4 aryl substituents for further manipulation. A number of versatile intermediates were generated.
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