Synthesis of the cardiotonic bemarinone, 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone, utilizing a direct metalation approach

Article abstract of DOI:10.1002/jhet.5570320312

Several methods for the synthesis of bemarinone, 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone, were explored with the most successful being a directed metalation route. Details of the lithiation and the subsequent reaction with electrophiles of 3',4'-dimeth