An efficient synthesis of 3-methyl-3-trifluoromethyl azetidin-2-one

DOI: 10.1016/0022-1139(94)03198-9

Source and publish data:

Journal of Fluorine Chemistry p. 57 - 60 (1995)

Update date:2022-08-05

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Authors:

Haddad, Mansour

Wakselman, Claude

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Article abstract of DOI:10.1016/0022-1139(94)03198-9

The Curtius rearrangement has been used as a key step for the transformation of the unsaturated ester 1 to the 3-trifluoromethylated 2-azetidinone 7 via a six-step synthesis. - Keywords: Trifluoromethyl: Azetidinone; β-Lactam; Curtius rearrangement; Antibiotics

Full text of DOI:10.1016/0022-1139(94)03198-9

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Product name:2-Benzyloxycarbonylamino-2-methyl-2-trifluoromethylpropanaldehyde

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