Synthesis and X-Ray Crystal Structure of 8,9-Dimethoxy-4-methyl-3-phenyl-2,3,5,6-tetrahydropyrroloisoquinolinium Iodide

Article abstract of DOI:10.1071/CH9951437

N-Methylation of 6,7-dimethoxy-1-(2'-phenylcyclopropyl)-3,4-dihydroisoquinoline (3b) with iodomethane in refluxing acetone gave the modified Cloke rearrangement product, 8,9-dimethoxy-4-methyl-3-phenyl-2,3,5,6-tetrahydropyrrolo<2,1-a>isoquinolinium iodide (5b), a new derivative of the pyrrolo<2,1-a>isoquinoline skeleton, together with the methiodide salt (4b) of (3b).The structure of (5b) was confirmed by X-ray crystallographic analysis.