Synthesis and Evaluation of 6,7-Dihydroxy-2,3,4,8,9,13b-hexahydro-1H-benzocycloheptabenzazepine, 6,7-Dihydroxy-1,2,3,4,8,12b-hexahydroanthrazepine, and 10-(Aminomethyl)-9,10-dihydro-1,2-dihydroxyanthracene as Conformationally

DOI: 10.1021/jm00013a015

Source and publish data:

Journal of Medicinal Chemistry p. 2395 - 2409 (1995)

Update date:2022-08-03

Topics:

Authors:

Snyder, Scott E.

Aviles-Garay, Felix A.

Chakraborti, Ratna

Nichols, David E.

Watts, Val J.

Mailman, Richard B.

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Article abstract of DOI:10.1021/jm00013a015

The present study was designed to define the geometry of the hydrophobic accessory region for binding of dopamine D¹ receptor ligands and to assess the relative importance of ethylamine side chain conformation for receptor affinity.Three compou

Full text of DOI:10.1021/jm00013a015

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