Synthesis and Evaluation of 6,7-Dihydroxy-2,3,4,8,9,13b-hexahydro-1H-benzocycloheptabenzazepine, 6,7-Dihydroxy-1,2,3,4,8,12b-hexahydroanthrazepine, and 10-(Aminomethyl)-9,10-dihydro-1,2-dihydroxyanthracene as Conformationally

Article abstract of DOI:10.1021/jm00013a015

The present study was designed to define the geometry of the hydrophobic accessory region for binding of dopamine D¹ receptor ligands and to assess the relative importance of ethylamine side chain conformation for receptor affinity.Three compou