TOTAL SYNTHESIS OF D-(+)-SHOWDOMYCIN FROM SYN-2,5-DISUBSTITUTED TETRAHYDROFURAN

DOI: 10.1016/0040-4039(95)00722-O

Source and publish data:

Tetrahedron Letters p. 4089 - 4092 (1995)

Update date:2022-08-05

Topics: Characterization Stereoselective synthesis Building blocks Protecting groups Isolation and Purification Retrosynthetic analysis Final steps Global Deprotection Bond Formation

Authors:

Kang, Sung Ho

Lee, Sung Bae

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Article abstract of DOI:10.1016/0040-4039(95)00722-O

D-(+)-Showdomycin, first isolated from Streptomyces showdoensis, has been synthesized starting from syn-2,5-disubstituted dihydrofuran 3.The key conversion was the functionalization of 2-thiophenylfuranyl group in 13 into maleic acid moiety in 12.

Full text of DOI:10.1016/0040-4039(95)00722-O

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