New Efficient Strategy for the Incorporation of (S)-Isoserine into Peptides

Article abstract of DOI:10.1021/jo00128a042

A new efficient synthesis of (S)-isoserine derivatives from (S)-malic acid using hexafluoroacetone as protecting and activating reagent is described.Via this route (S)-isoserine is obtained as mono- and diactivated species suitable for the incorporation of isoserine into the N- and C-terminal positions of peptides.