Synthesis of 8-membered cyclic sulfamides: Novel HIV-1 protease inhibitors

Article abstract of DOI:10.1016/0040-4039(95)01319-D

One pot synthesis of pseudo C2 symmetric (2S,6S)-2,6-dihydroxy-1,7-diphenylhept-4-one in high enantiomeric purity has been developed and the intermediate was used for the synthesis of 8-membered cyclic sulfamides.