β-Ketoaldehydes in the synthesis of 6-alkyl-3-cyano-2(1H)-pyridinethiones

Article abstract of DOI:10.1007/BF00698508

An efficient synthesis of 6-alkyl-3-cyano-2(1H)-pyridinethiones by the reactions of the sodium salts of β-ketoaldehydes with cyanothioacetamide was developed.Pyridinethiones undergo selective S-alkylation with haloacetonitriles and haloacetophenones followed by cyclization to the corresponding thieno<2,3-b>pyridines. - Key words: 6-alkyl-3-cyano-2(1H)-pyridinethiones, cyanothioacetamide, cyclization, thieno<2,3-b>pyridines.