Russian Chemical Bulletin p. 707 - 711 (1995)
Update date:2022-08-03
Topics:
Frolova, N. G.
Zav'yalova, V. K.
Litvinov, V. P.
An efficient synthesis of 6-alkyl-3-cyano-2(1H)-pyridinethiones by the reactions of the sodium salts of β-ketoaldehydes with cyanothioacetamide was developed.Pyridinethiones undergo selective S-alkylation with haloacetonitriles and haloacetophenones followed by cyclization to the corresponding thieno<2,3-b>pyridines. - Key words: 6-alkyl-3-cyano-2(1H)-pyridinethiones, cyanothioacetamide, cyclization, thieno<2,3-b>pyridines.
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