A predictable enantioselective total synthesis of (+)-clavularin A

Article abstract of DOI:10.1055/s-1995-4061

Cycloadduct 9 was transformed into vinylsilane 11d in a conjugate addition-alkylation sequence. Epoxidation and subsequent hydrolysis provided the clavularin adduct 14, which on flash vacuum pyrolysis (FVP) gave (+)-clavularin A (1) in 91% yield.