Journal fur Praktische Chemie - Chemiker-Zeitung p. 508 - 515 (1995)
Update date:2022-08-02
Topics:
Lindauer, Dirk
Beckert, Rainer
Billert, Thomas
Doering, Manfred
Goerls, Helmar
The aminolysis of bis-imidoylchloride 1 derived from oxalic acid with several diamines and aminoalcohols was investigated.At room temperature diamines 2 as well as aminoalcohols 7 give mainly the cyclic amidines 3 and mixed amidine-imidates 8 in moderately up to good yields.While cis-1,2-diaminocyclohexane yields at room temperature the bicyclic amidine 3a, the trans isomer reacts to 3b only when heated for several hours.Depending on the conditions, the racemic 1,2-diaminopropane 2h gives derivatives of pyrazine 3h or the open-chain amidine 5 resulting from an oxidative aromatization and subsequent hydrolysis.Histamine 2i and 1,8-diamino-3,6-dioxaoctane 2p react selectively with 1 to seven- respectively twelve-membered heterocycles 3i and 3p.The mixed aliphatic and aromatic diamines 2n, o show an anomalous behaviour leading to 2,2'-bis-chinazolines 3n, o.In comparison with acyclic oxalic amidines the new cyclic derivatives show less molecular dynemic in their nmr spectra.In some cases, a s-trans-arrangement of the amidine substructure was observed.
View MoreShanghai shibo Chemical Co., Ltd
Contact:+86-021-60753516
Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
JiangXi Hong Run Chemical Co., Ltd
Contact:+86-0791-88521351
Address:XingHuo industrial zone in YongXiu county
Lianyungang Yunbo Chemical Co.,Ltd.
Contact:518-81066110
Address:B907,Dongsheng"Mingdu Square,21-2 East Chaoyang Road,Xinpu,(sale department)
Changsha Yihai Chemical Technology Co.,ltd
Contact:0731- 85620465
Address:Room 23005, unit 2, the northern building of Xiangsong international building , NO.259 Shaoshan Road , Changsha , Hunan, China.(mainland)
NingBO Hong Xiang Biochem.Co.Ltd
website:http://www.hxbiochem.com
Contact:0574-66003444
Address:Ning Bo Bei Lun
Doi:10.1139/v01-029
(2001)Doi:10.1055/s-0032-1318110
(2013)Doi:10.1039/c9cc08372c
(2020)Doi:10.1016/0040-4039(95)01409-B
(1995)Doi:10.1039/c19660000548
(1966)Doi:10.1021/jm00021a012
(1995)