Synthesis and dopamine receptor binding studies of homochiral 8-aminopyrido[1,2-a]indoles

Article abstract of DOI:10.1002/ardp.19953280712

Starting from L-aspartic acid the preparation of 8-aminopyrido[1,2-a]indole derivatives as benzo-fused analogs of the dopamine autoreceptor agonist 1 is reported. The key step of the synthesis is the Tf₂O induced cyclization of the 1,2-amino al