Synthesis of L-chiro-inositol and (-)-conduritol F from D-sorbitol by a highly stereoselective intramolecular pinacol coupling promoted by samarium diiodide

Article abstract of DOI:10.1016/0957-4166(95)00246-L

A synthesis of L-chiro-inositol and (-)-conduritol F starting from readily available D-sorbitol is described. The route involves as a key step an efficient one-pot sequence consisting of the Swern oxidation of a 1,6-diol followed by a highly stereoselecti