Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5]

DOI: 10.1016/j.bmcl.2005.09.031

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 186 - 190 (2006)

Update date:2022-08-03

Topics:

Authors:

Bennett, Frank

Saksena, Anil K.

Lovey, Raymond G.

Liu, Yi-Tsung

Patel, Naginbhai M.

Pinto, Patrick

Pike, Russel

Jao, Edwin

Girijavallabhan, Viyyoor M.

Ganguly, Ashit K.

Loebenberg, David

Wang, Haiyan

Cacciapuoti, Anthony

Moss, Eugene

Menzel, Fred

Hare, Roberta S.

Nomeir, Amin

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Article abstract of DOI:10.1016/j.bmcl.2005.09.031

As part of a detailed study, the syntheses, biological activities, and pharmacokinetic properties of hydroxylated analogues of the previously described broad spectrum antifungal agents, Sch 51048 (1), Sch 50001 (3), and Sch 50002 (4), are described. Based on an overall superior profile, one of the alcohols, Sch 56592 (2), was selected for clinical studies.

Full text of DOI:10.1016/j.bmcl.2005.09.031

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