Journal of Fluorine Chemistry p. 113 - 122 (1995)
Update date:2022-07-29
Topics:
Namavari, Mohammad
Satyamurthy, N.
Barrio, Jorge R.
6-Fluorodopamine was regioselectively synthesized in good yields from N-(trifluoroacetyl)-3,4-di-t-butoxycarbonyloxy-6-(trimethylstannyl)phenylethylamine (6) via a fluorodestannylation reaction using F2, OF2 or CH3COOF followed by acid hydrolysis.Similarly, 6-fluoro-m-tyramine (14) and 4-fluoro-m-tyramine (20) were prepared from their corresponding trimethylstannyl derivatives.All precursors and products were fully characterized by multinuclear NMR spectroscopy and high resolution mass spectrometry. - Keywords: Dopamine neurotransmission; Norepinephrine synthesis; Dopamine agonist; 6-<18F>fluorodopamine; Fluorodestannylation
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Doi:10.1016/0957-4166(95)00367-X
(1995)Doi:10.1016/0008-6215(95)00096-C
(1995)Doi:10.1016/0040-4039(95)01629-V
(1995)Doi:10.1016/0022-328X(95)05703-R
(1995)Doi:10.1021/om950624r
(1996)Doi:10.1002/jhet.4344
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