The stereoselective Horner-Wittig reaction with phoshine oxides: Synthesis of hindered Z alkenes via Luche reduction

Article abstract of DOI:10.1016/0040-4039(95)01629-V

The natural anti selectivity of the Horner-Wittig reaction with phospine oxides is reduced when there is a branched chain next to the new C=C double bond. A better approach is Luche reduction of the corresponding ketones which gives high anti selectivity when the branched chain is placed on the side chain next to the phosphine oxide.