A 'one pot' synthesis of polysubstituted pyridines from metallated alkylphosphonates, nitriles and α,β-unsaturated ketones

Article abstract of DOI:10.1016/0040-4039(96)00850-7

A simple and efficient synthesis of polysubstituted pyridines is described. The key step is based on the regioselective addition of lithiated β-enaminophosphonates 5 to unsaturated carbonyl compounds 3. Pyridines 1 can also be obtained in 'one pot' reaction from phosphonates 6 when these compounds are metallated followed by addition of nitriles and unsaturated carbonyl compounds.