Enantiodivergent Synthesis of the Key Intermediate for Aphanorphine by Chemoenzymatic Process

Article abstract of DOI:10.1016/0040-4020(95)00784-6

A short chemoenzymatic route to both enantiomers of the key intermediate (12) in the preparation of aphanorphine is described.Enzymatic hydrolysis of the prochiral malonate (8) followed by selective reduction was achieved in very high ee (>99percent).