Homologues of anti-HIV active isodideoxynucleosides

Article abstract of DOI:10.1016/0040-4020(95)00626-J

The synthesis of a homologous series of compounds related to the anti-HIV active class of compounds known as (S,S)-isodideoxynucleosides has been completed by a convergent route using a modified carbohydrate intermediate. This precursor, synthesized from D-glucose, was coupled with a variety of natural purine and pyrimidine bases to regiospecifically afford the desired new class of compounds.